Fuse Science is a Recruitment Agency specialising in Biopharmaceutical, Biotechnology, Cell Therapy, Pharmaceuticals and Medical Device jobs
About Fuse ScienceFuse Science Jobs
Fuse Science Services
At Fuse Science Recruitment we understand that each job your looking to fill is unique and recruitment requirements can change
About Fuse Science
Fuse Science work with some of the most cutting edge scientific organisations across the UK and Europe who are all striving to make a difference to people’s lives.
Fuse Science Testimonials
Fuse Science are proud to be serving the scientific recruitment industry providing quality staff to our high calibre clients. Here’s what some of them have to say about us.
Fuse Science Jobs
Fuse Science Recruitment work with some of the most cutting edge scientific organisations, here are some of the vacancies we are currently recruiting for.
About Fuse Science
Biopharmaceuticals
Biotechnology
Cell Therapy
Pharmaceuticals
Medical Device
Recruitment
Fuse Science work with some of the most cutting edge scientific organisations across the UK and Europe who are all striving to make a difference to people’s lives. Our focus over the past few years has been in Biopharmaceuticals, Biotechnology, Cell Therapy, Pharmaceuticals and Medical Device making us the go to Recruitment Agency for both clients and candidates.
We offer a tailored and bespoke individual service to meet our clients and job seekers needs across a variety of specialist roles. Over the years we have learnt to take time to listen to what our clients’ needs are as every role is unique. We have developed a passion within this niche industry which is why it is important to us to take time in selecting the very best candidate for the job.
Since Fuse Science began it has been their aim to work with the top scientific organisations today helping them to grow and recruit the best talent around. We also work closely with our candidates to help them to realise their full potential.
To find out more about how you can make your career spark please contact us:
01223 298038 or info@fusescience.co.uk
Hot Jobs
Fuse Science Recruitment has an exciting opportunity for an experienced Scientist within CMC Development to join a cutting-edge biotechnology company in Cambridgeshire, this is a permanent position with competitive salaries and benefits package. Check out the full job specification below:
The Role
As the CMC Analytical Development Scientist you’ll support the development of portfolios including internal analytical testing and support of outsourced analytical activities at CROs and CDMOs
- Develop and utilise novel analytical techniques to support lead-candidate developability, protein characterisation, and identification of potential Critical Quality Attributes (pCQAs) for the Development Pipeline
- Independently and proactively support in-process testing, product quality analysis and forced degradation studies (determining mechanisms of degradation or protein-protein interactions as required)
- Represent the CMC Analytical Development Function as a Subject Matter Expert (SME) on internal and external project teams
- Lead, coach and mentor the internal scientific teams engaged in analytical support, to facilitate product candidate molecule development
- Produce and maintain CMC Analytical Development records, SOPS and documentation to support regulatory submissions and inspections.
- Maintain awareness of and ensure compliance with policies and cGMP procedures relating to outsourced cGMP manufacture
- Support CMC pre-formulation development and stability evaluation
- Design and execute Clinical compatibility studies
You
Ideally, you’ll have a PhD or equivalent and relevant industry experience of biotherapeutics analyticsl development and characterisation across multiple technology platforms including chromatography, electrophoresis, biophysical and MS Characterisation.
Extensive experience of protein analytical/physiochemical strategies and characterisation of complex biological products e.g. antibody/Bi-specifics along with strong communication skills, with the ability to build strong relationships with key individuals at CMC Suppliers and interact effectively in multidisciplinary teams both internally and externally.
Package
Competitive salaries and a generous benefits package are on offer including Pension, Private Health and Dental, Life Insurance, Bonus and Share Options. There are also great opportunities for career progression within this expanding company.
Company
A leading Biotechnology Company who are developing next generation Humabody therapeutics derived from a unique transgenic platform all focused to build an exciting portfolio of novel oncology products in areas of high unmet need.
Apply Now
To be considered for the CMC Analytical Development Scientist please send your CV to Natasha Robbins at Fuse Science Recruitment via the apply now button.
Job Features
| Job Category | Biotechnology |
Position: Senior Project Manager/Project Director Location: Cambridge Salary: Competitive The Role A growing Biotechnology company are currently looking to recruit a Senior Project Manager/Project Director to join their Project Management Group. As the Senior Project Manager/Project Director you’ll manage and lead pre-clinical/early clinical programs. Key Responsibilities:
- Project manage the delivery of robust preclinical and translational activities for bispecific antibodies in close collaboration with cross functional team members and in particular clinical operations.
- Work with team to develop and translate project strategy into operational plans and budget that meets internal and external stakeholder requirements.
- Monitor all project activities at external contractors and ensure appropriate timelines, budget and quality standards are met.
- Management of project budgets (forecast and active tracking) and maintaining active project plans (using MS Project)
- Participate in data review discussions and contribute to data interpretation
- Contribute to the preparation of regulatory briefing documents and preclinical/clinical elements of regulatory submission documents
- Create and manage risk registers
- Assist with the writing of manuscripts and development of abstracts and presentation
Job Features
| Job Category | Biotechnology |
Position: Formulation & Protein Analytics Team Leader
Location: Cambridge
Salary: Competitive A leading Biopharmaceutical Company are currently expanding their Antibody Discovery Department and looking to recruit a dynamic scientist to lead the formulation and protein analytics team. The Role As the Formulation and Protein Analytics Team Leader you’ll manage the recently formed team in the biophysical assessment and analysis of lead molecules, the use of label-free protein interaction technology supporting early discovery and development of lead candidate’s formulation and stability testing. Responsibilities • Generation and delivery of high quality and well documented data packages for advancing drug candidates that support CMC manufacture and regulatory submissions
• Stability and biophysical assessment of drug candidates with industry-standard readouts and associated documentation for both discovery and pre-CMC candidates
• Managing of the label-free in-house expert team involving the latest BLI and SPR technology to support discovery and development
• Line Managerial responsibility for the team
• Present key findings and provided solutions to project teams, development teams and discovery
• Support on-going lab based work as required You Ideally, you’ll have a PhD with significant employment experience within a similar role. You’ll have in-depth and demonstrated experience in antibody-drug based formulation and analytics with extensive expertise pf protein biophysical characterisation procedures and techniques – DLS, SLS, DSC, DSF and HPLC method development. A strong knowledge of excipient and buffer systems designed to maximise antibody stability, data packages to support CMC is essential for the role. Experience with label-free technology such as SPR and BLI(Octet) is very desirable. Package Competitive salaries and a generous benefits package are on offer including Pension, Private Health and Dental, Life Insurance, Bonus and Share Options. You’ll also be working for a growing organisation who value their employees and offer great opportunities for career development. Company A leading Biopharmaceutical company who are focused on the discovery and development of fully human monoclonal antibody drugs across several therapeutic antibody programmes in Immune-oncology, auto-immunity, haematology and infectious disease. Apply Now To be considered for the Formulation and Protein Analytics Team Leader please send your CV to Natasha Robbins at Fuse Science Recruitment via the apply now button.
Job Features
| Job Category | Biopharmaceutical |
Full Time, Permanent
Cambridgeshire
Posted 7 years ago
Position: Research Scientist/Senior Scientist – Antibody Selection and Engineering
Location: Cambridge
Salary: Competitive A leading Biotechnology Company are currently expanding their Antibody Selection and Engineering department and looking to recruit a motivated Research Scientist or Senior Scientist to join the team. The Role As the Research Scientist / Senior Scientist you’ll have high level practical skills and technical knowledge specific to your areas of responsibility in Antibody Selection and Engineering and will be expected to deliver projects against agreed plans and quality targets. You’ll maintain expected levels, both personally and in the team of laboratory practices, record keeping and HSE standards. Responsibilities • Antibody Selection using Phage Display and/or other in vitro display systems
• Antibody Screening and characterisation using ELISA and Alphascreen, HTRF, Affinity determination (BIAcore, Octet) and protein stability assays
• Next Generation sequencing for antibody repertoire mining for monitoring selections
• Managing direct reports at Senior Scientist level You Ideally, you’ll have a PhD with significant employment experience within a similar role. You’ll be experienced in Antibody Selection and characterisation and be confident in antibody selection using phage and/or other in vitro display systems. Experience in Mammalian cell culture including cell line maintenance, transfection, selection, cloning and Analytical flow cytometry (FACS) is also desirable. Package Competitive salaries and a generous benefits package are on offer including Pension, Private Health, Life Insurance and Bonus. You’ll also be working for a growing organisation who value their employees and offer great opportunities for career development. Company A leading Biotechnology company who are the preferred supplier for antibody discovery and engineering libraries and technologies based on its proprietary DNA synthesis and protein display/selection methods. Apply Now To be considered for the Research Scientist/ Senior Scientist in Antibody Selection and Engineering please send your CV to Natasha Robbins at Fuse Science Recruitment via the apply now button.
Job Features
| Job Category | Biotechnology |
Position: IT Manager
Location: Cambridge
Salary: Competitive The Role A leading Biopharmaceutical Company are looking to recruit a IT Manager to join their Informatics team. As the IT Manager you’ll be responsible for maintaining, planning and expanding the growing IT system portfolio and actively influencing the development of the company’s future IT strategy. You’ll support and advise teams on providing state-of-the-art, reliable and cost-effective IT solutions to business problems and meet business goals both within the UK and Taiwan offices. Responsibilities
• Ensure the integrity, control and effective operation of all computer systems, telecoms equipment, related applications, hardware and software that is used within the company
• Manage a team of two in-house IT technicians and our external IT support partner, to deliver an exceptional customer service experience
• Prepare and keep current the 3 year IT, Systems & Telecoms Strategy Plan
• Recommend information technology strategies, policies and procedures by identifying problems, evaluating trends and anticipating requirements
• Manage secure network access for all users
• Implementation and periodic testing of Informatics disaster recovery and backup plan
• Manage the IT budget and support the selection, installation and maintenance of all software and hardware (administrative, laboratory, etc.)
• Oversee the maintenance of an inventory of all software applications (administrative and laboratory) and hardware assets
• Ensure adherence with software licensing agreements and terms and conditions
• Develop, extend and oversee a rapid-response IT helpdesk support facility for all company users to provide the following:
o Efficient and timely setup of new joiner’s IT / telecoms equipment.
o User issue resolution on individual laptop, desktop and mobile devices.
o Resolving laboratory equipment hardware/software issues.
o Provide user training, support, advice and feedback.
• Manage external relationships with third-party providers
• Liaise with external support services and management to schedule downtime, maintenance and upgrades
• Manage IT team meetings and team-wide prioritisation
• Work with in-house staff, consultants and contractors to deliver or extend projects such as knowledge management using Sharepoint, archiving, infrastructure upgrades
• Maintain professional and technical knowledge by attending educational workshops, reviewing professional publications, establishing personal networks, benchmarking state-of-the-art practices and participating in professional societies
You You’ll have substantial, prior professional experience in an IT Management capacity and ideally have a Degree in Computer Science, Information Systems or a related area. Knowledge of software and hardware configuration management processes and best practice is essential as well as being an all-rounder who is at ease “rolling-up” sleeves to get into detail to provide an internal helpdesk function for employees while having a wider vision to develop top-level plans and strategies. Proven expertise with Windows and Microsoft Applications (Outlook, Word, Excel, PowerPoint, Visio, SharePoint and Project) and experience of data compliance requirements and data security ideally in GDPR. Working within a Similar environment for a Biotechnology company is preferred and knowledge of LIMS such as BioVia ELN, Genedata Biologics and GraphPad Prism. Package Competitive salaries and a generous benefits package are on offer including Pension, Private Health and Dental, Life Insurance, Bonus and Share Options. You’ll also be working for a growing organisation who value their employees and offer great opportunities for career development. Company A leading Biopharmaceutical company who are focused on the discovery and development of fully human monoclonal antibody drugs across several therapeutic antibody programmes in Immune-oncology, auto-immunity, haematology and infectious disease. Apply Now To be considered for the IT Manager please send your CV to Natasha Robbins at Fuse Science Recruitment via the apply now button.
Job Features
| Job Category | Biopharmaceutical |
Position: Medical Director – Immuno-Oncology and Inflammation
Location: Cambridge
Salary: Competitive A leading Biopharmaceutical Company are looking to recruit two medical directors or senior medical director to support their growing portfolio with one focused on Immuno-Oncology and one on Inflammation. The Role As the Medical Director you’ll be a key figure in the medical team, reporting to the Chief Medical Officer you’ll provide strategic medical guidance and lead development of experimental immuno-oncology and /or anti-inflammatory antibodies in the portfolio, beginning with the candidate selection phase of preclinical development and continuing through proof-of-concept (POC) Responsibilities • Provide strategic medical guidance for the development of new antibodies that are in preclinical development
• Lead the early program teams, beginning at the time of Development Candidate (DC) nomination and approval to conduct toxicology studies
• Create the clinical development plan (CDP) that supports development beyond POC, combining medical knowledge with the expertise of other functions (eg clinical pharmacology, toxicology etc)
• Integrate preclinical information (pharmacology, toxicology, PK) and interpret its implications for clinical development, as articulated in the Investigator Brochure (IB)
• Collaborate with clinical scientists to develop, interpret and report clinical trial protocols
• Apply medical knowledge to guide the safe, ethical and efficient conduct of the trails under their responsibility, be knowledgeable of GCP guidelines and strive to maintain compliance with them You Ideally, you’ll have a Degree of Medicine (MD), PhD or Board certification in a relevant therapeutic area. Expert knowledge in the main field of interest Immuno-oncology or Inflammation along with significant industry/biotech experience of early-phase clinical trials. Thorough working knowledge of application of PK/PD and Biostatistics to clinical development and clinical trials is essential and proven ability to analyse and interpret efficacy and safety data. Package Competitive salaries and a generous benefits package are on offer including Pension, Private Health and Dental, Life Insurance, Bonus and Share Options. You’ll also be working for a growing organisation who value their employees and offer great opportunities for career development. Company A leading Biopharmaceutical company who are focused on the discovery and development of fully human monoclonal antibody drugs across several therapeutic antibody programmes in Immune-oncology, auto-immunity, haematology and infectious disease. Apply Now To be considered for the Medical Director please send your CV to Natasha Robbins at Fuse Science Recruitment via the apply now button.
Job Features
| Job Category | Biopharmaceutical |
Posted 7 years ago
Position: Senior Scientist CMC – Bioassay Development
Location: Cambridge
Salary: Competitive The Role A leading Biopharmaceutical Company are looking to recruit Senior Scientist to develop in house biological assay capabilities in support of outsourced CMC activities. Responsibilities
• Develop and optimise cell based biological assay methods, cell lines and reagents for use in GMP product release and stability testing
• Assess Discovery based bioassay methods for their utility as potency assays for GMP product release and stability testing
• Manage the transfer of suitable bioassays to third party contract manufacturing organisations
• Ensure methods are designed to meet current industry and regulatory guidance
• Evaluate and implement new technologies as required
• Authoring of relevant sections of regulatory submissions
• Contribute to on-going MOA assay development within the group
• Provide support to project teams throughout the product development process
You Ideally, you’ll have a BSc, MSc or PhD in an in vitro cell based subject and have significant relevant experience in bioassay development and validation for use in GMP and tech transfer. Experience in therapeutic monoclonal antibody potency assay methods (target binding/agonism, ADCC) and associated microplate platforms (luminescence, MSD, spectrophotometric) is also essential. Package Competitive salaries and a generous benefits package are on offer including Pension, Private Health and Dental, Life Insurance, Bonus and Share Options. Company A leading Biopharmaceutical company who are focused on the discovery and development of fully human monoclonal antibody drugs across several therapeutic antibody programmes in Immune-oncology, auto-immunity, haematology and infectious disease. Apply Now To be considered for the Senior Scientist in CMC Bioassay Development please send your CV to Natasha Robbins at Fuse Science Recruitment via the apply now button.
Position: Principal Scientist – Team Leader Assay Development
Location: Cambridge
Salary: Competitive A growing Biotechnology company are currently looking to recruit a Principal Scientist to lead their assay development team. The Role As the Principal Scientist within Assay Development you’ll be responsible for designing, developing and optimising in vitro biological assays and establishment of Standard operating procedures and protocols, and will be expected to be an ambassador for quality in analytical procedures. Key Responsibilities:
• To lead a team performing experiments involving the development of controlled methods for pre-clinical analytics (e.g. PK assays), drug candidate characterisation and clinical release assays
• To lead assay development projects involving cross-functional teams, independently design and execute project goals, plans and milestones in alignment with established programme strategy
• To contribute a broad technical skill set as well as understanding of rigorous approach to assay development and maintenance, ensuring robust methods are available to span drug discovery and development processes
• To lead outsourcing activities covering bioanalytical assays as well as release bioassays and reagent generation
• Ensure the team performs experiments and data management activities in a robust manner and produces quality data to inform decision making on projects
• Carry out and support on-going analyses of data generated, to identify issues and implement necessary changes.
• Implement best practice and keep up to date with regulatory guidelines with a view to transferring methods into a regulated environment to be used under GLP and GMP regulations
• Identify critical project-related issues and successfully implement plans to overcome them to ensure the achievement of goals/milestones.
• Read scientific and technical literature and keep up with the new trends and techniques related to role You Ideally you’ll have a PhD or equivalent industry experience where you’ve gained considerable industry experience with a focus on assay development for a regulated environment and extensive experience in structured assay design, record keeping and understanding of factors affecting assay robustness and levels of data quality.
Solid understanding of statistics applied to bioassays and proficiency in PK Assays, cell biology, in vitro Immuno Assays, Flow Cytometry, In Vitro Cell activation assays, ADCC, CDC, ADCP, Cell Culture, Analysis and purification of primary murine and human immune cells and immunological phenotyping.
You’ll have proven experience in a small team designing and optimising biological and immunological assays, extensive experience in structured assay design and a good track record of research outputs. Company A leading Biotechnology Company who have gone through significant growth and are focused on the development of Bispecific Antibodies for the treatment of serious diseases including Immune Oncology. Salary and Benefits Salaries are very competitive and discussed during the interview process with benefits including Pension Scheme, Life Assurance and Private Medical Insurance. This company has gone through significant growth the past 12 months and they offer great career progression opportunities. Apply Now To be considered for the Principal Scientist in Assay Development and have the chance to work for a cutting edge company please send your CV to Natasha Robbins at Fuse Science Recruitment via the apply now button
Job Features
| Job Category | Biotechnology |
Position: IT and Systems Manager
Location: Cambridge
Salary: Competitive The Role A leading Biotechnology Company are looking to recruit a IT and Systems Manager who can provide proactive leadership of and drive the development of the IT Function. Responsibilities
• Ensure the integrity, control and effective operation of all computer systems, telecom equipment, related applications, hardware and software that is used within offices and laboratories
• Prepare and keep current IT / Systems / Telecoms Strategy Plans and recommend improvements and developments in IT strategies, policies, and procedures by identifying problems, evaluating trends and anticipating requirements through strategic discussions with R&D, Finance and Business Development
• Manage secure network access for all users, including disaster recovery and back-up plans
• Manage IT budget and support the selection, installation and maintenance of all software and hardware
• Oversee an inventory of all software applications and ensure adherence with software licensing agreements
• Develop, implement, and oversee rapid response IT hosting and helpdesk support for all users
• Manage all external relationships with third-party providers, including the scheduling of downtime, maintenance and upgrades
• Manage IT Steering Committee meetings
• Develop functionality and maintain the upkeep, architecture and structural integrity of the intranet and external website, working with internal groups and external website designers on content and modifications
You You’ll have substantial, prior professional experience in an IT Management capacity and ideally have a Degree in Computer Science, Information Systems or a related area. Knowledge of software and hardware configuration management processes and best practice is essential as well as being an all-rounder who is at ease “rolling-up” sleeves to get into detail to provide an internal helpdesk function for employees while having a wider vision to develop top-level plans and strategies. Proven expertise with Windows and Microsoft Applications (Outlook, Word, Excel, PowerPoint, Visio, SharePoint, Viso and Project) and experience of UNIX, Linux, Oracle and programming (Java, C++) Working within a Similar environment for a Biotechnology company is preferred and knowledge of LIMS such as Genedata Biologics and GraphPad Prism. Package Competitive salaries and a generous benefits package are on offer including Pension, Private Health and Dental, Life Insurance, Bonus and Share Options. You’ll also be working for a growing organisation who value their employees and offer great opportunities for career development. Company A leading Biotechnology Company who have gone through significant growth and are focused on the development of Bispecific Antibodies for the treatment of serious diseases including Immune Oncology. Apply Now To be considered for the IT and Systems Manager please send your CV to Natasha Robbins at Fuse Science Recruitment via the apply now button.
Job Features
| Job Category | Biotechnology |
Position: Research Scientist – Antibody Generation Group
Location: Cambridge
Salary: Competitive A leading Biopharmaceutical company are looking to recruit an outstanding laboratory based scientist to join the Antibody Generation group. The Role As the Research Scientist in Antibody Technology Development you’ll work on a key programme on the development of a bi-specific antibody platform for drug discovery and work in a multi-disciplinary team. Responsibilities:
• As a key part of the Antibody Generation Group, the candidate will be responsible for designing strategy and capturing the rare cells of interest using flow cytometry
• Design, assess and implement cell sorting strategies in a project-dependent manner supported by strong scientific rationales
• Analyse, summarise and present data to internal/project teams as well as to wide company/external collaborators
• Co-ordinate work within the Antibody Generation Group as well as with other group members
• Support downstream workflow in molecular cloning and mammalian cell culture You Ideally, you’ll have a PhD in Immunology and strong research experience in Flow Cytometry in particular with Single Cell Sorting, familiar with various flow analysis software (FlowJo, Kaluza, FACSDiva, MACSQuantify) You must have great attention to detail to be able to think quickly and identify errors to troubleshoot and have experience with Cell Sorter (BD Aria II, III or Fusion). Company A leading Biopharmaceutical company focused on the discovery and development of fully human monoclonal antibody drugs who are leaders in their field and focused in advancing several therapeutic antibody programmes in immuno-oncology, auto-immunity, haematology and infectious disease. Salary and Benefits Salaries are very competitive and discussed during the interview process with benefits including Pension Scheme, Life Assurance and Private Medical Insurance. This company has gone through significant growth the past 12 months and they offer great career progression opportunities. Apply Now To be considered for the Research Scientist in Antibody Technology Development and have the chance to work for a cutting-edge company please send your CV to Natasha Robbins at Fuse Science Recruitment via the Apply Now button
Job Features
| Job Category | Biopharmaceutical |
Position: Senior Research Associate – Flow Cytometry
Location: Cambridge
Salary: Competitive A leading Biopharmaceutical company are looking to recruit an outstanding laboratory based scientist to join the Antibody Generation group. The Role As the Senior Research Associate in Antibody Generation you’ll support key programmes on the development of a bi-specific antibody platform for drug discovery and work in a multi-disciplinary team. Responsibilities:
• Support the Antibody Generation Group in our drug discovery process
• Single-cell sort rare B cells of interest by flow cytometry
• Support other related activities as required, such as PCR cloning, NGS & mammalian cell transfection (training will be provided) You Ideally, you’ll have a BSc or MSc in Immunology, Biochemistry, Molecular Biology or related discipline and expertise in Flow Cytometry, single cell sorting and Molecular biology and assay techniques such as PCR and ELISA. Company A leading Biopharmaceutical company focused on the discovery and development of fully human monoclonal antibody drugs who are leaders in their field and focused in advancing several therapeutic antibody programmes in immuno-oncology, auto-immunity, haematology and infectious disease. Salary and Benefits Salaries are very competitive and discussed during the interview process with benefits including Pension Scheme, Life Assurance and Private Medical Insurance. This company has gone through significant growth the past 12 months and they offer great career progression opportunities. Apply Now To be considered for the Senior Research Associate in Antibody Technology Development and have the chance to work for a cutting-edge company please send your CV to Natasha Robbins at Fuse Science Recruitment via the Apply Now button
Job Features
| Job Category | Biopharmaceutical |
Position: Research Associate – Protein Sciences Location: Cambridge Salary: Competitive The Role As the Research Associate in Protein Sciences you’ll play a key role in the continuous advancement of the Immune oncology platform and contribute to drug discovery and development. The role is largely lab-based working under supervision of the senior scientist and you’ll be responsible for protein purification, characterisation, filtrations and sterility testing of antigens, antibody fragments and bi-specific mAb2 Molecules. Key Responsibilities:
- Perform protein purification by a variety of chromatographic techniques using AKTA system.
- Perform downstream protein characterisation, filtrations and sterility testing.
- Generate high quality results within the expected timelines. Research should be consistent and thorough.
Job Features
| Job Category | Biotechnology |
Position: Principal Translational Scientist Location: Cambridge Salary: Competitive An exciting opportunity to join a growing Biotechnology company in Cambridge as a Principal Translational Scientist. The Role As the Principal Translational Scientist, you’ll assist in the development and implementation of the translational strategy to our novel pipeline of early phase bispecific mAb2 molecules for immune-oncology. You’ll guide internal and external teams to produce quantitative translational datasets to enable the selection of best-in-class molecules and a well-defined data package to enable successful clinical development Key Responsibilities:
- Responsible for providing technical and scientific contribution to the biomarker strategy for multiple IO bispecific mAb projects
- Work as part of a multidisciplinary team to develop the translational and clinical biomarker strategy
- Liaise closely with preclinical pharmacology and discovery groups to characterize the fundamental biology of targets and translation across species to ensure appropriate endpoints are measured for target engagement and pharmacodynamic effects.
- Perform the appropriate scholarship required to develop hypothesis driven approaches to the targeted use of quantitative biomarkers
- Oversee the technical and operational aspects of mechanistic biochemical biomarker analysis (e.g. sample collection through to data generation and interpretation)
- Continually assess the latest technologies available and provide input to the internal and external capabilities required to support the portfolio needs.
- To represent the client at external meetings including contributions at meetings by way of presentations, scientific committee representation and publications.
- Drive a culture of inclusivity and active engagement with translational goals and thereby translational understanding across the company.
Job Features
| Job Category | Biopharmaceutical, Biotechnology |
Position: Scientist –Assay Development Location: Cambridge Salary: Competitive
A growing Biotechnology company are currently looking to recruit a Scientist to join the assay development team for a 12 month FTC. The Role As the Scientist within Assay Development you’ll be responsible for designing, developing and optimising in vitro biological assays and establishment of Standard operating procedures and protocols, and will be expected to be an ambassador for quality in analytical procedures. Key Responsibilities:
- To lead experiments involving the development of controlled methods for pre-clinical analytics (e.g. PK assays), drug candidate characterisation and clinical release assays
- To lead assay development projects involving cross-functional teams, independently design and execute project goals, plans and milestones in alignment with established programme strategy
- To contribute a broad technical skill set as well as understanding of rigorous approach to assay development and maintenance, ensuring robust methods are available to span drug discovery and development processes
- Ensure experiments and data management activities result in robust, quality data to inform decision making on projects
- Carry out on-going analyses of data generated to identify issues and implement necessary changes.
- Support best practice and keep up to date with regulatory guidelines with a view to transferring methods into a regulated environment to be used under GLP and GMP regulations
- Identify critical project-related issues and successfully implement plans to overcome them to ensure the achievement of goals/milestones.
- Read scientific literature and keep up with the new trends and techniques related to role
Job Features
| Job Category | Biotechnology |
Position: Research Associate – Immune-Oncology Location: Cambridge Salary: Competitive A leading Biopharmaceutical Company are looking to recruit Research Associate in Immune-Oncology to join their Pharmacology and Translational Science Group. The Role As the Research Associate in Immune-Oncology you’ll undertake primary cell-based assays to support the advancement of the Immuno-Oncology portfolio. Responsibilities
- Support in vitro and ex vivo assessment of antibody mode action, including pharmacodynamic effects on tumour and on immune cells (techniques include cellular staining, cytokine release and gene expression)
- Responsible for conducting in vitro assays including cell proliferation, apoptosis, ADCC and CDC assays
- Work with minimal supervision in the design, implementation and the generation of experimental data supporting project decisions
- Provide an active role in project team meetings
Job Features
| Job Category | Biotechnology |